Situated in northeastern Arkansas along I-55, Blytheville affords residents a true small-town feel with a historic downtown stretched along Main Street, brimming with shops, salons, restaurants, and diverse cultural offerings. Downtown Blytheville hosts various productions at the Ritz Civic Center, book clubs and signings at That Bookstore in Blytheville, and rotating exhibits at the Delta Gateway Museum.

Blytheville offers plenty of recreational opportunities at the Thunder Bayou Golf Links, Youth Sportsplex, and Walker Park. The Mississippi River is close to Blytheville as well. Options for day trips and weekend getaways are abundant with Memphis, Tennessee and Saint Louis, Missouri both within short driving distance of Blytheville.